Oxford News
Statins do not cause the majority of side effects listed in package leaflets
Cardiovascular disease results in around 20 million deaths worldwide and causes around a quarter of all deaths in the UK. Statins are highly effective drugs that lower LDL (‘bad’) cholesterol levels and have been repeatedly proven to reduce the risk of cardiovascular disease. However, there have been concerns about possible side effects.
The researchers gathered data from 23 large-scale randomised studies from the Cholesterol Treatment Trialists’ Collaboration: 123,940 participants in 19 large-scale clinical trials comparing the effects of statin therapies against a placebo (or dummy tablet), and 30,724 participants in four trials comparing more intensive versus less intensive statin therapy.
“>Video of Statins and side effects: large study finds no excess risk for most reported symptoms
They found similar numbers of reports for those taking the statins and those taking the placebo for almost all the conditions listed in package leaflets as possible side effects. For example, each year, the number of reports of cognitive or memory impairment was 0.2% in those taking the statins, but also 0.2% in those taking the placebo. This means that while people may notice these problems whilst taking statins, there is no good evidence that they are caused by the statin.
Key findings:
- There was no statistically significant excess risk from statin therapy for almost all the conditions listed in package leaflets as potential side effects.
- Taking a statin did not cause any meaningful excess of memory loss or dementia, depression, sleep disturbance, erectile dysfunction, weight gain, nausea, fatigue or headache, and many other conditions.
- There was a small increase in risk (about 0.1%) for liver blood test abnormalities. However, there was no increase in liver disease such as hepatitis or liver failure, indicating that the liver blood test changes do not typically lead to more serious liver problems.
Christina Reith, Associate Professor at Oxford Population Health and lead author of the study, said: ‘Statins are life-saving drugs used by hundreds of millions of people over the past 30 years. However, concerns about the safety of statins have deterred many people who are at risk of severe disability or death from a heart attack or stroke. Our study provides reassurance that, for most people, the risk of side effects is greatly outweighed by the benefits of statins.’
Previous work by the same researchers established that most muscle symptoms are not caused by statins; statin therapy caused muscle symptoms in only 1% of people during the first year of treatment with no excess thereafter. It has also shown that statins can cause a small increase in blood sugar levels, so people already at high risk may develop diabetes sooner.
Professor Bryan Williams, Chief Scientific and Medical Officer at the British Heart Foundation, said: ‘These findings are hugely important and provide authoritative, evidence-based reassurance for patients. Statins are lifesaving drugs, which have been proven to protect against heart attacks and strokes. Among the large number of patients assessed in this well-conducted analysis, only four side effects out of 66 were found to have any association with taking statins, and only in a very small proportion of patients.
‘This evidence is a much-needed counter to the misinformation around statins and should help prevent unnecessary deaths from cardiovascular disease. Recognising which side effects might genuinely be associated with statins is also important as it will help doctors make decisions about when to use alternative treatments.’
Professor Sir Rory Collins, Emeritus Professor of Medicine and Epidemiology at Oxford Population Health and senior author of the paper said: ‘Statin product labels list certain adverse health outcomes as potential treatment-related effects based mainly on information from non-randomised studies which may be subject to bias. We brought together all of the information from large randomised trials to assess the evidence reliably. Now that we know that statins do not cause the majority of side effects listed in package leaflets, statin information requires rapid revision to help patients and doctors make better-informed health decisions.’
All of the trials included in the analyses were large-scale (involving at least 1,000 participants) and tracked patient outcomes for a median of nearly five years. The trials were double-blind, meaning that neither the trial participants nor those managing the participants or leading the study knew who was receiving which treatment, to avoid potential biases due to knowledge of treatment allocation. The list of possible side effects was compiled from those listed for the five most commonly prescribed statins.
The paper, ‘Assessment of adverse effects attributed to statin therapy in product labels: a meta-analysis of double-blind randomised controlled trials,’ is published in The Lancet.
Oxford News
£7 billion East West Rail Oxford to Milton Keynes row solved
Instead, Chiltern Railways has started hiring Customer Service Inspectors—roles that closely resemble the duties of traditional guards.
Oxford’s new railway line to Milton Keynes has been complete for almost two years, but passenger trains still aren’t running.
The move comes after the Government’s initial instruction to adopt driver-only operation, with unions demanding that a guard be present.
The new inspectors, to be based at the Bletchley depot—home to East West Rail services—will undertake tasks including customer care, revenue protection, making on-train announcements, and reporting or rectifying faults.
While a second staff member will typically be present, train doors will still be operated by drivers, meaning the absence of a second staff member in rare cases will not prevent a service from running—mirroring practices commonly seen south of London.
45 drivers have been recruited for the new service, but no guards.
An internal government document confirms issues at Winslow station will not obstruct operation, and the fleet of trains has been upgraded with ‘Superpower mode’ to enhance acceleration and meet a tight timetable.
The project delays have already taken a significant financial toll.
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Six two-carriage trains have accumulated £2.6m in costs due to delays in their lease.
Currently idle in a Bletchley depot, these units are costing the Department for Transport money without generating any fare income.
Previously, the rail industry attributed setbacks to complications in finalising Winslow station.
However, observers note this typically does not stop a line from launching, as seen with the Northumberland Line, which managed to start operations even with incomplete stations.
A total of 45 drivers have been recruited for the new service, but the absence of guards, also known as ‘train managers’, has proved more contentious.
The Government has been pushing for ‘Driver-Controlled’ or ‘Driver-Only Operation’—a cost-saving method introduced widely on London commuter lines in the 1980s.
However, this system’s extension to new lines has faced staunch resistance from rail unions, who have fielded several disputes over the years, the most recent of which extended more than four years with South Western Railway.
The stalemate over guards has ultimately stalled the Oxford-Milton Keynes route, but the introduction of the ‘Customer Service Inspector’ role now seems to pave the way for the resolution, hinting at imminent rides for the eagerly awaiting passengers.
The Government previously said trains from Oxford to Milton Keynes are being lined up to appear in the December rail timetable.
In a written statement, rail minister Lord Peter Hendy said: “Chiltern worked with Network Rail, the Department for Transport and other operators on the December 2026 timetable and services have been timetabled between Oxford, Winslow, Bletchley and Milton Keynes.”
Oxford News
215 homes, care home and retirement village plans approved
Cherwell District Council has backed the plans to transform the 14-hectare brownfield site at Islip Fuel Depot, a former RAF fuel depot near Islip village.
The plans include 150 homes, of which half will be affordable, up to a 70-bed care home and up to 65 retirement units, subject to 20 conditions.
These will replace the decommissioned Islip Fuel Depot off Bletchingdon Road, which was taken over by the Esso Petroleum Company in the 1960s before being shut down in 1991.
The current state of the decommissioned Islip Fuel Depot (Image: Barwood Development Securities Ltd and NCM Real Re)
Under approval conditions, the developer must contribute almost £5m to local services, councils and police, under S106 contributions.
More than £300,000 will go towards local services. This includes improvements to Household Waste Recycling, Kidlington Library and Islip Medical Practice, or an identified primary care project in the local area.
The district council requested more than £1m in contributions towards enhancing community hall facilities, outdoor and indoor sport provision, a community development worker and fund, and public art.
Oxfordshire County Council requested more than £3.6m in financial contributions, including almost £3m towards primary and secondary education.
Thames Valley Police requested more than £30,000 towards additional staff, vehicles, premises, equipment and ANPR cameras.
In the case officer’s report, Katherine Daniels noted that while the proposal would result in the development of a substantial site on the edge of the village with some landscape and visual harm, weight is given to the benefits.
One of those is the council not being currently able to demonstrate a five-year supply of deliverable housing land.
She said: “The delivery of market housing attracts significant positive weight and the affordable housing provision attracts very substantial positive weight given the acute need for affordable homes across the District.
“National policy and guidance recognise the pressing need to provide accommodation for older persons and specialist housing to meet changing demographics. The proposal would make an important contribution towards addressing that need.”
Weight is also given to the redevelopment of the “largely redundant” brownfield site.
Illustrative views of the proposed development at the decommissioned Islip Fuel Depot (Image: Barwood Development Securities Ltd / NCM Real Re)
She said: “The proposal would secure remediation of contaminated land, environmental improvements and the beneficial reuse of previously developed land in accordance with national and local planning objectives.”
The site was first thought to be within Oxford Green Belt but officers concluded the site constitutes Grey Belt land.
She said: “The proposal would not result in unacceptable impacts in respect of highway safety, heritage assets, ecology, flooding, drainage, contamination, residential amenity or infrastructure provision.
“These matters can be appropriately addressed through planning conditions and planning obligations.”
Oxford News
Private school defends use of sprinklers during hosepipe ban
Radley College is an independent full boarding school for boys aged 13 to 18, set in the countryside between Oxford and Abingdon.
It occupies the historic Radley Hall estate, with grounds partly landscaped by Capability Brown in the eighteenth century, and has grown to more than 850 acres in the 2020s.
The private school has now come under fire after locals spotted sprinklers being used on the grounds last week despite a hosepipe ban.
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The sprinklers at Radley College during the hosepipe ban. (Image: Public submission)
Thames Water announced at the end of last month that a temporary ban would start at 12.01am on Thursday, July 23.
This was due to an exceptionally dry spring, three official heatwaves, record‑breaking temperatures and prolonged high demand.
Sprinklers have been in operation at the Oxfordshire site in recent days, but the school has defended this, citing the water use as fulfilling health and safety needs.
A Radley College spokesperson said: “The safety and wellbeing of everyone using our facilities remains our priority.
“During periods of dry weather, pitches can become extremely hard, increasing the risk of injury to players.
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Radley College Chapel and Mansion. (Image: Edmund Blok / Radley College)
“To minimise this risk, some of our pitches are watered for health and safety reasons using water from our on-site borehole.”
Pupils partake in a variety of sports throughout the year including rugby union, hockey, rowing, football, cricket, lawn tennis and athletics.
A statement from Thames Water backs up the school’s use of water to maintain the pitches.
The water company said: “Whilst elements of the ban do restrict some business water use, schools and sporting fields / playing surfaces are still permitted to irrigate with mains water.
“This is due to health and safety requirements.”
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The hosepipe ban remains in place currently across Oxfordshire with no end date yet set despite some rainfall last week and more expected in the coming days.
A spokesperson for Thames Water recently said: “We’ll continue to monitor water levels and conditions across the region.
“We’ll lift the hosepipe ban as soon as conditions allow.
“Thank you to everyone who has already reduced their water use- your support is helping protect water supplies for communities and the environment.”
Formerly known as St Peter’s College, Radley, the school was founded in 1847 by Anglican clergymen William Sewell and Robert Corbet Singleton.
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It was inspired by the Oxford Movement to create a Christian, collegiate-style school with an emphasis on beauty and privacy.
As of the 2026/27 academic year, Radley charges £21,216 per term for boarders, inclusive of VAT, meaning annual fees in excess of £63,000.
Notable former pupils include Oxford-born reality TV star and entrepreneur Jamie Laing, best known for Made in Chelsea and his confectionery brand Candy Kittens.
Former England cricket captains Andrew Strauss and Ted Dexter, as well as comedian Peter Cook, all attended Radley College as well.
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