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Oxford University’s new rabies vaccine could save lives

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Developed by researchers at the University of Oxford, the new vaccine ChAdOx2 RabG has shown promising results in a clinical trial in Tanzania, offering stronger and longer-lasting protection in both adults and children compared to currently available options.

Rabies causes an estimated 59,000 deaths each year, mainly in Africa and Asia, with children at highest risk.

Most existing vaccines require multiple clinic visits, making them difficult to deliver in low-resource settings.

Professor Sandy Douglas of the Jenner Institute at the University of Oxford, who developed the vaccine and is the study’s senior author, said: “Rabies is entirely preventable, yet it still causes tens of thousands of deaths each year, mostly among children.

“Our findings suggest that a single-dose vaccine could offer a practical and affordable way to protect vulnerable populations, particularly in rural and low-resource settings.”

The trial involved 63 adults and 111 children aged two to six, who were given either the new vaccine or a licensed rabies vaccine for comparison.

In adults, the new vaccine generated antibody levels around five times higher than those seen with a single dose of existing vaccines after one year.

In children, it produced levels more than eight times higher.

It also outperformed the World Health Organisation’s recommended two-dose regimen in children.

Nearly all children given the new vaccine maintained protective antibody levels one year post-vaccination.

Dr Adam Ritchie, first author of the study and senior vaccinologist at the Jenner Institute, said: “If these results are confirmed in larger trials, this vaccine could be a game changer for rabies prevention.

“In a world where wealthy travellers can be vaccinated but children living in the same high-risk regions rarely are, it has the potential to simplify vaccination, reduce costs, and ultimately save lives.”

The vaccine also produced rapid immune responses, raising the possibility that it could be used after exposure as part of emergency treatment, though further research is needed.

A follow-up study is planned to start later this year.

Rabies is most commonly spread through dog bites.

Global prevention efforts focus on vaccinating dogs and providing post-exposure treatment to people.

However, the need for multiple vaccine doses makes routine immunisation difficult in areas with limited healthcare infrastructure.

Researchers hope that a single-dose, low-cost option could make preventive vaccination more feasible in high-risk regions.

The trial is ongoing, with participants to be followed for up to 5.5 years to assess the duration of protection.

Larger studies will be required before the vaccine can be approved for wider use.

The full study is published in The Lancet Infectious Diseases.





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King Charles and Camilla absent from Oxfordshire royal funeral

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Mourners, including members of the Royal Family, travelled to a small village in the county for the funeral of Lady Pamela Hicks on Saturday (June 13).

The service for the 97‑year‑old took place at St Bartholomew’s Church in Brightwell Baldwin, between Wallingford and Watlington.

Lady Pamela died last week at her home in the village, where she had lived for many years with her late husband, interior designer David Hicks.

READ MORE: Mourners arrive for Royal Family funeral in Oxfordshire village

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Among the mourners were Lady Helen Taylor, daughter of Prince Edward, and Penelope Knatchbull, Countess Mountbatten of Burma.

There was no sign of King Charles or Queen Camilla, though, as the funeral came on the same day as Trooping the Colour, the King’s official London birthday parade.

Nevertheless, mourners paid their respects outside St Bartholomew’s Church as the coffin was carried inside, before following the procession for the service.

The small parish church is close to The Grove, the family house that became her long‑term base in Oxfordshire.

READ MORE: Legendary chef heralds shock return of closed Oxfordshire pub

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According to the published order, the funeral was arranged in line with Lady Pamela’s wishes, with rousing hymns but no formal sermon or eulogy during the service.

Lady Pamela was a first cousin of the late Prince Philip and a great‑great‑granddaughter of Queen Victoria.

She was also a bridesmaid at the 1947 wedding of the then Princess Elizabeth and Lieutenant Philip Mountbatten.

READ MORE: Christian Horner and Geri Halliwell to make £45m life decision

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The 97-year-old later served as a lady‑in‑waiting to Queen Elizabeth II and accompanied the then Princess on the 1952 tour of Kenya.

This was when news came through of King George VI’s death and Elizabeth’s accession to the throne.

Following her death on June 5, King Charles paid a warm tribute, saying he was “greatly saddened to learn of the death of Lady Pamela Hicks, a sorrow tempered by the fondest memories and deepest gratitude for her long life and loyal service to Queen Elizabeth.”

In the statement released by Buckingham Palace, he added that her “warmth, wit and perspicacity always made such an impression” and that she would be “so dearly missed by all those who knew and loved her.”

READ MORE: Award-winning UK private school to mark 75th anniversary with celebration

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Lady Pamela is survived by her three children, Edwina, Ashley and India, and several grandchildren, many of whom were expected to attend today’s village service.

Brightwell Baldwin is a small rural parish in South Oxfordshire, about four and a half miles north‑east of Wallingford and close to the foot of the Chiltern Hills.

The village, whose name comes from the Old English for “bright spring”, had a population of just over 200 at the last census and is centred around a handful of stone cottages, farms and the church.

St Bartholomew’s itself dates back to the 13th and 14th centuries, with later medieval additions, and is regarded as one of south Oxfordshire’s most interesting historic churches.





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England transplant team lift the Four Nations trophy

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Led by manager Daley Cross, a renal and transplant youth worker at the Churchill Hospital, the England men’s side claimed the title with a 9-1 win over Scotland in the final.

The tournament, held in Dingwall at the Global Energy Stadium, brought together more than 60 transplant recipients from England, Scotland, Wales, and Northern Ireland, with each team showcasing the life-changing impact of organ donation and the resilience of transplant recipients.

Mr Cross said: “While it’s fantastic to bring the trophy home, the most important thing is the message behind the tournament.

“This is about showing what organ donation makes possible. Every player is living proof of the difference it can make.”

Among the England squad were two kidney transplant recipients cared for at Churchill Hospital – defender Robert Collins, 23, who received a kidney from his uncle in 2009, and goalkeeper Adam Martin, 35, who received a transplant from his sister in 2023.

Mr Collins, from Bedfordshire, said: “I’ve always loved playing football. When I was ill, I couldn’t play at all and I really missed it.

“Having a transplant has given me the chance to get back on the pitch and enjoy the game again.

“Being part of this team makes it even more special. There’s a real bond between us, one that extends beyond football – we’ve all been given a second chance.

“Every time we play, it’s a celebration of that. Scoring goals and winning along the way also helps.”

Mr Martin, from Banbury, said: “Representing your country is always an honour, but doing it alongside all the other transplant recipients – and in recognition of our donors – means so much more.

“I’ll always be forever grateful for the support the team offers and also to my sister for giving me a second chance at life.”

England finished the tournament unbeaten, securing dominant group-stage wins against Scotland (10-0), Northern Ireland (8-2), and Wales (7-0) before winning the final.

Mr Cross, who has worked at Oxford University Hospitals for 11 years, said: “We’re proud of what we’ve achieved on the pitch, but above all we want to raise awareness and encourage more people to consider organ donation.

“It truly saves and transforms lives.”

The tournament also featured public outreach to encourage sign-ups to the NHS Organ Donor Register.

England’s transplant team will now set their sights on the Transplant Football World Cup in Frankfurt, Germany, taking place later this year.

The competition will bring together teams from around the world to promote organ donation and celebrate the achievements of transplant recipients on a global stage.





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Harry Potter star Miriam Margolyes: ‘People don’t like Jews’

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The actress, who was born and grew up in the city, is well known to audiences around the world after starring as Professor Sprout in several of the Harry Potter films.

Known for her character actor work across film, television, and stage, she received the BAFTA for Best Supporting Actress for her role as Mrs Mingott in Martin Scorsese’s 1993 film, The Age of Innocence.

Ms Margolyes was awarded an OBE in 2002 for services to drama, but there were calls for this to be taken back last year.

READ MORE: Oxford Union to host Tommy Robinson for debate despite outcry

The 85-year-old, who is Jewish, has said that “people don’t like Jews” whilst speaking at the Hay Festival in Powys.

Ms Margolyes added that her Jewish identity has shaped her “whole life” and added: “What your parents teach you and what you learn from the community you live in.”

Addressing concerns about rising antisemitism, she told the audience: “Nobody likes me to say this, but I’m going to say it – people don’t like Jews.”

She reflected on how, after the Holocaust – “when millions of Jewish people, and people from other backgrounds, were killed by the Nazis during World War Two” – there was a period when people “realised that they couldn’t say nasty things about Jews because terrible things happened to Jews and they must be sympathetic, so it stopped.”

However, she added that, over time, when “people with no morals who happened to be Jewish” appeared in public life, “the knives came out again, and they have never been put away.”





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