Oxford News
Oxford University spinout Dark Blue Therapeutics acquired to advance leukaemia treatment
The acquisition is expected to help accelerate the development of a new type of targeted treatment for leukaemia, with the potential to improve outcomes for patients. It is also hoped that this treatment could be expanded to other cancers.
The scientific foundations of the programmes were built on discoveries made by Oxford researchers including Oleg Fedorov, Cassandra Adams, Gilian Farnie, Kilian Huber and Paul Brennan in the Centre for Medicines Discovery; Christian Siebold in the Division of Structural Biology (STRUBI) at the Nuffield Department of Medicine; and Thomas Milne and Nicholas Crump in the MRC Weatherall Institute of Molecular Medicine at the Radcliffe Department of Medicine.
The research was further strengthened by complementary expertise across the University, including the Dunn School of Pathology, notably the groups of Professor Monika Gullerova and Professor Ivan Ahel. The work was also supported by the Structural Genomics Consortium (SGC), a global public-private partnership focused on open science.
The move from academic discovery to early-stage drug development began within Lab282, a £13 million partnership between the University of Oxford, the drug discovery company Evotec and Oxford Sciences Enterprises (OSE), and Bristol Myers-Squibb. Lab282 was created to bridge the gap between research and drug discovery, supporting promising projects as they move towards commercialisation.
Commenting on the role of Lab282 as an incubator, Professor Paul Brennan of the Centre for Medicines Discovery said: ‘We set out to create a model that could reduce risk early by combining strong biology with high-quality chemistry, while keeping future development in mind. Lab282 was designed to help move promising academic science into a setting where it could be developed further with industry partners. Amgen’s investment in the science demonstrates how the Lab282 model can progress promising academic research to a stage attractive to global pharmaceutical partners.’
This translational work laid the foundations for the creation of a new company to take the programme forward. Dark Blue Therapeutics an Oxford spinout, was founded to advance this research towards new medicines – focused on developing first-in-class small-molecule therapies that target cancer-driving proteins previously considered difficult to treat.
Professor Thomas Milne explains: ‘The company is developing a novel approach to treating leukaemia by targeting proteins that drive cancer growth in aggressive blood cancers, including acute myeloid leukaemia (AML). Our research showed that this approach can inhibit the growth of leukaemia cells while largely sparing healthy cells, raising the prospect of a more effective and better-tolerated treatment.’
The lead drug candidate developed by Dark Blue Therapeutics is now in preclinical development, with studies under way to enable testing in patients. Amgen’s acquisition of the company will provide the resources and expertise needed to take the programme into clinical trials.
John Pollard, the Chief Scientific Officer at Dark Blue and a visiting Professor of Drug Discovery at the University reflected: ‘The discovery of this exciting new class of drugs demonstrates the enormous potential in the Oxford ecosystem that can be realised when ground breaking disease insights from the Universities’ world leading scientists are leveraged by expert industrial drug hunters in a truly collaborative manner.’
The Amgen deal reflects the strength of Oxford’s wider innovation ecosystem, combining world-leading science, incubator support, spin-out expertise, and industry partnership. Together, these elements create a framework through which promising biomedical research can be advanced from discovery to commercial development, supporting the progression of future therapeutic programmes emerging from Oxford.
Oxford News
Oxford stalker to appear again at magistrates’ court
Zac Sanger-Reynolds, of North Hinksey Lane in Oxford, previously plead guilty to stalking at High Wycombe Magistrates’ Court on Friday, April 28.
He will appear at the Buckinghamshire court on Thursday, June 4 for an application to vary a restraining order.
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Sanger-Reynolds was handed the order in April after a mother-of-two spoke to the Oxford Mail about his ‘obsession’ after she became uninterested in him after two dates.
He was told to complete 100 hours of un-paid, supervised work within 12 months and undertake 26 days of rehabilitation.
He was also ordered to pay £199, including £114 for the victim surcharge and £85 to the Crown Prosecution Service.
Oxford News
Controversial Oxfordshire homes approved despite concerns
Construction company Taylor Wimpey was granted the development on appeal in 2017 for up to 95 homes at Thames Farm, off Reading Road in Lower Shiplake.
It has since reduced this to 84 to provide adequate drainage because “the land is unstable and vulnerable to sinkholes”.
Taylor Wimpey said the new drainage plans will ensure there are no off-site impacts relating to surface water and this will include a basin on the western part of the site.
Members of the Thames Farm Action Group, which represents Shiplake residents, have concerns about the environmental impact of the scheme, which they say has no precedent in the UK.
The ground would have to be injected with grout and concrete to keep stable despite it sitting on top of an aquifer that supplies water to nearby towns.
READ MORE: Police action continues over dual carriageway after dangerous races
Freddie van Mierlo has consistently objected to the plans (Image: Contributed)
In July 2025, the planning committee of South Oxfordshire District Council voted to refuse the ground-stabilisation application despite a recommendation for approval.
Councillors cited concerns about possible impacts on the aquifer and public water supply.
The formal refusal notice stated the application “failed to demonstrate that the proposed engineering operations would not pose an unacceptable risk to the aquifer and nearby public water abstraction points”.
But now the plans have been given the go ahead by a separate planning inspector.
Despite objections from the district council the project appears to have been given the go ahead.
Freddie Van Mierlo, MP for Henley and Thame, said: “I will be working with The Thames Farm Action Group, Henley Town Council, Shiplake Parish Council and Harpsden Councils to ensure their voices are heard.”
The new report states there is a risk, but it’s “an acceptable level of risk” for the area.
Oxford News
Rick Stein ‘nearly killed’ ex-wife in crash at Oxford University
The TV cook, now best known for his seafood restaurants and BBC travel series, grew up on a farm in Churchill, a small village just outside the market town of Chipping Norton.
Mr Stein later went on to study English at Oxford, further strengthening his ties to Oxfordshire alongside his upbringing in the Cotswolds.
During his time as a student, he maintained a long‑term relationship with Jill Stein, who would go on to co‑found and run the business side of his restaurant empire.
READ MORE: Mary Berry talks turning 91 after finding ‘joy’ at retirement home
The Cotswolds village of Churchill, in Oxfordshire (Image: Wikimedia Commons / Philip Halling)
The couple later married, remained together for many years while building their businesses, and eventually divorced after their relationship broke down.
In a recent interview with The Times, the 76-year-old revisited a near‑fatal incident in Oxford which she says has left her with permanent hearing loss.
She had moved to London while Mr Stein was at Oxford, and had arranged to meet him in Oxford for a weekend.
Ms Stein discovered that he was instead drinking at a student club and confronted him when he eventually arrived at the pub where she was waiting.
READ MORE: ‘It broke me’- Emma Watson opens up in emotional admission
Jack Stein, Jill Stein, Charlie Stein, Rick Stein, and Edward Stein. (Image: Newsquest)
He recalled in the book that he reacted “angrily but also very lustfully”, but remembering that night, Ms Stein told The Times: “He did nearly kill me.”
Driving fast on the Oxford bypass, Mr Stein crashed into roadworks and hit a 44‑gallon drum, sending an oil lamp through the windscreen and into her head.
Ms Stein said: “He could see that I was bleeding quite a lot and I said, ‘oh, just put me to bed. I’ll be fine.’ And he thought, even though he was drunk, ‘no, I’m not sure about this’.
“‘I think I’ll ring the ambulance’. So he rang the ambulance and, because it was a 999 call, the police came along as well, and they breathalysed him.”
READ MORE: Jeremy Clarkson ‘parties in pub until 4.30am’ celebrating win
The crash occurred while Rick Stein was studying at Oxford University. (Image: Murray Bosley)
At the John Radcliffe Hospital, a brain surgeon operated on her, and during her interview with The Times, Ms Stein pointed to her left side and added: “And that’s why I can’t hear in this ear.”
Asked how long it took her to forgive him, she reflected: “I never blamed him really. I don’t know why, but I didn’t.”
Mr Stein later began a relationship with Sarah Burns, a publicist who had worked with his company, while he was still married to Jill Stein.
The affair eventually led to the end of his first marriage, and he went on to marry his second wife in 2011, with the couple now living between Australia and the UK.
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