Oxford News
Oxford University spinout Dark Blue Therapeutics acquired to advance leukaemia treatment
The acquisition is expected to help accelerate the development of a new type of targeted treatment for leukaemia, with the potential to improve outcomes for patients. It is also hoped that this treatment could be expanded to other cancers.
The scientific foundations of the programmes were built on discoveries made by Oxford researchers including Oleg Fedorov, Cassandra Adams, Gilian Farnie, Kilian Huber and Paul Brennan in the Centre for Medicines Discovery; Christian Siebold in the Division of Structural Biology (STRUBI) at the Nuffield Department of Medicine; and Thomas Milne and Nicholas Crump in the MRC Weatherall Institute of Molecular Medicine at the Radcliffe Department of Medicine.
The research was further strengthened by complementary expertise across the University, including the Dunn School of Pathology, notably the groups of Professor Monika Gullerova and Professor Ivan Ahel. The work was also supported by the Structural Genomics Consortium (SGC), a global public-private partnership focused on open science.
The move from academic discovery to early-stage drug development began within Lab282, a £13 million partnership between the University of Oxford, the drug discovery company Evotec and Oxford Sciences Enterprises (OSE), and Bristol Myers-Squibb. Lab282 was created to bridge the gap between research and drug discovery, supporting promising projects as they move towards commercialisation.
Commenting on the role of Lab282 as an incubator, Professor Paul Brennan of the Centre for Medicines Discovery said: ‘We set out to create a model that could reduce risk early by combining strong biology with high-quality chemistry, while keeping future development in mind. Lab282 was designed to help move promising academic science into a setting where it could be developed further with industry partners. Amgen’s investment in the science demonstrates how the Lab282 model can progress promising academic research to a stage attractive to global pharmaceutical partners.’
This translational work laid the foundations for the creation of a new company to take the programme forward. Dark Blue Therapeutics an Oxford spinout, was founded to advance this research towards new medicines – focused on developing first-in-class small-molecule therapies that target cancer-driving proteins previously considered difficult to treat.
Professor Thomas Milne explains: ‘The company is developing a novel approach to treating leukaemia by targeting proteins that drive cancer growth in aggressive blood cancers, including acute myeloid leukaemia (AML). Our research showed that this approach can inhibit the growth of leukaemia cells while largely sparing healthy cells, raising the prospect of a more effective and better-tolerated treatment.’
The lead drug candidate developed by Dark Blue Therapeutics is now in preclinical development, with studies under way to enable testing in patients. Amgen’s acquisition of the company will provide the resources and expertise needed to take the programme into clinical trials.
John Pollard, the Chief Scientific Officer at Dark Blue and a visiting Professor of Drug Discovery at the University reflected: ‘The discovery of this exciting new class of drugs demonstrates the enormous potential in the Oxford ecosystem that can be realised when ground breaking disease insights from the Universities’ world leading scientists are leveraged by expert industrial drug hunters in a truly collaborative manner.’
The Amgen deal reflects the strength of Oxford’s wider innovation ecosystem, combining world-leading science, incubator support, spin-out expertise, and industry partnership. Together, these elements create a framework through which promising biomedical research can be advanced from discovery to commercial development, supporting the progression of future therapeutic programmes emerging from Oxford.
On Wednesday, September 2, it was the Concours judging and private viewings to dominate the agenda for the day.
Twelve Concours classes were held across almost a century of motoring, including The Golden Age of Motoring, 100 Years of Carrrozzeria Touring, La Dolce Vita, 60 Years of the Lamborghini Miura and Passione Ferrari.
Two new classes also made their debut for 2026, Rare Breeds of the Digital Age and Hypercar Heaven, which recognise the growing importance of contemporary performance cars within the international collector market.
Judging will take place across Wednesday and Thursday, with the show field bringing together a 70-strong collection of classics, supercars and hypercars from around the world.
Some of the cars include Aa Maserati 8C 3000, Alfa Romeo Sprint Berlinetta, a one-off Maserati 3500GT Spyder Prototipo by Vignale, a very early Porsche 356 Split Window Coupé, Aston Martin DB3S, Lamborghini Miura P400S, Bizzarrini 5300GT, Ferrari 250 GT Series 1 Cabriolet, Bugatti EB110 Prototype, Aston Martin Valiant Prototype and the extraordinary Bugatti Bolide, one of just 40 produced worldwide.
Helen Pike has decided to step down as Master of Magdalen College School at the end of the 2026/27 academic year, the school in east Oxford announced in March.
MCS is one of the top performing schools in the country, ranking in the top 20 independent secondary schools in The Sunday Times Parent Power Schools Guide 2026.
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The new academic year will start next week, with Ms Pike preparing for one more year in charge before she hands over to her successor, who will take over in September 2027.
The first female Master at MCS, Ms Pike guided the board of governors to one of the most significant decisions in the school’s history, to become fully co-educational from 2027.
While there has been a co-educational sixth form at the school for 15 years, the school last month announced it will become fully co-educational over the coming decade.
Ms Pike said earlier: “I love MCS, and it is a perennial privilege to lead this remarkable school.
“Being Master of MCS is a brilliant job, and I am declaring my intention early in order to give MCS the very best opportunity to find the right Master for September 2027. I shall continue to do all in my power to further the fortunes of this wonderful school until then.
“I look forward to a new phase in my own professional life, one that builds on all that I have enjoyed and achieved in my career during the past 30 years.
“Having encouraged many cohorts of pupils to take sensible risks and to do something creative and different when the time feels right, I am doing just that.”
During Ms Pike’s tenure, MCS has been recognised as a Top 20 Independent School and South East School of the Year by the Sunday Times and won Independent School of the Year for Social Mobility.
Thanking her in his letter to the school community, chair of governors, Bob Price, said earlier this year: “Helen is an outstanding leader and will go with our sincere gratitude and warm thanks for her exceptional headship.
“She will leave the school in excellent shape for her successor.”
Recruitment for a replacement for Ms Pike is now under way.
Last month, Ms Pike congratulated pupils on their “outstanding success” in this year’s A-Level exams, after more than a quarter of pupils (43) achieved three A*s or more and 25 secured all A*s.
In total, 39 pupils from the 2026 cohort are heading to Oxbridge, while 22 have secured places to study medicine.
As part of the school’s expansion plans, MCS is preparing to build a new Science, Library and Partnerships building.
A spokeswoman said the new building will offer an exciting opportunity to reimagine the senior school site as staff look ahead to full co-education.
She added earlier: “With a vision to create a sector-leading science building in the centre of Oxford, the development will enable us to support an ambitious and forward-looking science curriculum, expanding to the emerging and rapidly advancing areas of robotics, AI and Big Data.”
Holding banners which read ‘For f**k’s sake, just stop oil’, the demonstrators took to the road in Parliament Square at noon today (Wednesday, September 2).
This was as Andy Burnham faced his first Prime Minister’s Questions, and many of the protestors glued themselves to the road.
The group demanded that the UK government stop approving all further oil and gas developments, and sign a Fossil Fuel Treaty to stop oil and gas extraction.
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Just Stop Oil say that the police are expected to arrest all those blocking the road, and that one lane has been left free of glued-on action takers to permit access for emergency vehicles.
Andy Burnham is due to make a decision on whether to allow more drilling for oil and gas in the North Sea.
Reverend James Crote, a Baptist Minister and grandfather from Chesterton near Bicester, said: “Today is my grandson’s first birthday. I have to take action for the sake of his future.
The 69-year-old added: “The government has been dilly-dallying about whether to say yes or no to the Rosebank oil field but, if we want a future for our children, there is no choice – it has to say ‘no’.
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“I am here as a Christian Minister because the Church has to speak out and demand that the government stops approving further oil and gas developments now. It’s time for us all to say ‘For God’s sake, Just Stop Oil’.”
Data from the Met Office indicates that 2026 was the hottest summer in UK recorded history, beating 2025, which was the previous hottest summer on record.
2026 was also one of the driest summers on record, delivering record-low food harvests.
Climbing temperatures have triggered wildfires across the country, and national fire chiefs said the wildfire risk facing the UK is “like nothing we have seen before”.
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Taking action, grandmother Victoria Ann Lynch-Staunton from Leamington Spa, said: “What is happening is beyond a tragedy.”
The 71-year-old added: “I beg everyone to join Just Stop Oil or governments will continue to prioritise endless growth and corporate profit over billions of lives – yours and your children.
“Wake up and smell the coffin. It is the responsibility of all of us to act now!”
A Just Stop Oil spokesperson said today: “We are all Just Stop Oil.
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“Every single person who fears deadly wildfires, devastating droughts, and spiralling food shortages is Just Stop Oil.
“The first duty of government is to keep the public safe – but by greenlighting oil and gas drilling, they endanger our survival while corporates and billionaires laugh their way to the bank.
“Every one of us feels alone and powerless in the face of this insanity, but we know there is massive political and public support for our demand.
“So we’re inviting everyone to join us at an online call on 3rd October 2026 – because it’s when we work together that we are powerful and win.”
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