Oxford News
Oxford scientists uncover how the brain resolves emotional ambiguity
Scientists at the University of Oxford have demonstrated, for the first time, that a key emotional centre deep in the human brain directly influences how we interpret ambiguous social cues.
In a new study, published in Neuron, researchers used low-intensity focused ultrasound to temporarily and non-invasively alter activity in the amygdala – a region known to be involved in emotion and affected in depression. They found that this changed how people responded to facial expressions, particularly when those expressions were emotionally unclear.
The findings provide rare causal evidence in humans about how the brain processes uncertainty in emotional situations, with potential implications for understanding mental health conditions.
Miriam Klein-Flügge, Associate Professor and Wellcome Henry Dale and ERC-UKRI Fellow at the Oxford Centre for Integrative Neuroimaging (OxCIN), said: ‘It has not been previously possible to change activity in deep areas of the human brain without requiring surgery. Oxford has been a key player in establishing a new, non-invasive neurostimulation technique called transcranial ultrasound stimulation (TUS), over many years, and this is the first study that applies this stimulation to the human amygdala – one of the key centres for emotion processing – while also measuring very precise neuroimaging signals to assess how we have changed the brain.’
What the study found
When the amygdala was temporarily modulated, participants became more likely to approach neutral (emotionally ambiguous) faces, suggesting they interpreted them more positively.
Participants also took longer to respond to neutral and happy faces, indicating increased difficulty distinguishing between similar emotional signals.
Brain imaging showed that stimulation reduced communication between the amygdala and other brain regions and altered its internal chemical balance.
Importantly, the effects were specific: learning from feedback was unchanged, and stimulating a different brain region produced different behavioural effects.
How the research was done
The team used a cutting-edge technique called transcranial focused ultrasound stimulation (TUS), which allows scientists to safely and precisely influence activity in deep brain regions without surgery.
Healthy volunteers received brief ultrasound stimulation targeting the amygdala before completing a behavioural task involving emotional facial expressions and decision-making. High-resolution brain scans were used to confirm that the stimulation had the intended biological effects.
The researchers measured these changes in multiple ways: they showed changes in important brain metabolites (GABA), and in the region’s functional connectivity, which indicates how it speaks to other parts of the brain. But they also showed changes in how people perceive ambiguous emotional expressions in faces.
Professor Klein-Flügge added: ‘This is a paper that we believe will shift and propel the field – the amygdala is a core region changed in mood disorders, including depression and anxiety, and while we applied ultrasound in healthy participants in this first study, an obvious next step is to see if abnormal amygdala metabolism can be restored in patients. There are still very few places worldwide that can do this type of research.
‘By showing that we can safely and precisely influence deep brain regions, this opens up exciting possibilities for future research and, potentially, new treatments. The next step is to see how these mechanisms operate in people with mood disorders.’
The researchers hope to apply this approach in clinical populations to better understand and potentially treat conditions such as depression, where emotional interpretation is often altered.
The paper, ‘Low-intensity focused ultrasound to human amygdala reveals a causal role in ambiguous emotion processing and alters local and network activity’, is published in Neuron.
On Wednesday, September 2, it was the Concours judging and private viewings to dominate the agenda for the day.
Twelve Concours classes were held across almost a century of motoring, including The Golden Age of Motoring, 100 Years of Carrrozzeria Touring, La Dolce Vita, 60 Years of the Lamborghini Miura and Passione Ferrari.
Two new classes also made their debut for 2026, Rare Breeds of the Digital Age and Hypercar Heaven, which recognise the growing importance of contemporary performance cars within the international collector market.
Judging will take place across Wednesday and Thursday, with the show field bringing together a 70-strong collection of classics, supercars and hypercars from around the world.
Some of the cars include Aa Maserati 8C 3000, Alfa Romeo Sprint Berlinetta, a one-off Maserati 3500GT Spyder Prototipo by Vignale, a very early Porsche 356 Split Window Coupé, Aston Martin DB3S, Lamborghini Miura P400S, Bizzarrini 5300GT, Ferrari 250 GT Series 1 Cabriolet, Bugatti EB110 Prototype, Aston Martin Valiant Prototype and the extraordinary Bugatti Bolide, one of just 40 produced worldwide.
Helen Pike has decided to step down as Master of Magdalen College School at the end of the 2026/27 academic year, the school in east Oxford announced in March.
MCS is one of the top performing schools in the country, ranking in the top 20 independent secondary schools in The Sunday Times Parent Power Schools Guide 2026.
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The new academic year will start next week, with Ms Pike preparing for one more year in charge before she hands over to her successor, who will take over in September 2027.
The first female Master at MCS, Ms Pike guided the board of governors to one of the most significant decisions in the school’s history, to become fully co-educational from 2027.
While there has been a co-educational sixth form at the school for 15 years, the school last month announced it will become fully co-educational over the coming decade.
Ms Pike said earlier: “I love MCS, and it is a perennial privilege to lead this remarkable school.
“Being Master of MCS is a brilliant job, and I am declaring my intention early in order to give MCS the very best opportunity to find the right Master for September 2027. I shall continue to do all in my power to further the fortunes of this wonderful school until then.
“I look forward to a new phase in my own professional life, one that builds on all that I have enjoyed and achieved in my career during the past 30 years.
“Having encouraged many cohorts of pupils to take sensible risks and to do something creative and different when the time feels right, I am doing just that.”
During Ms Pike’s tenure, MCS has been recognised as a Top 20 Independent School and South East School of the Year by the Sunday Times and won Independent School of the Year for Social Mobility.
Thanking her in his letter to the school community, chair of governors, Bob Price, said earlier this year: “Helen is an outstanding leader and will go with our sincere gratitude and warm thanks for her exceptional headship.
“She will leave the school in excellent shape for her successor.”
Recruitment for a replacement for Ms Pike is now under way.
Last month, Ms Pike congratulated pupils on their “outstanding success” in this year’s A-Level exams, after more than a quarter of pupils (43) achieved three A*s or more and 25 secured all A*s.
In total, 39 pupils from the 2026 cohort are heading to Oxbridge, while 22 have secured places to study medicine.
As part of the school’s expansion plans, MCS is preparing to build a new Science, Library and Partnerships building.
A spokeswoman said the new building will offer an exciting opportunity to reimagine the senior school site as staff look ahead to full co-education.
She added earlier: “With a vision to create a sector-leading science building in the centre of Oxford, the development will enable us to support an ambitious and forward-looking science curriculum, expanding to the emerging and rapidly advancing areas of robotics, AI and Big Data.”
Holding banners which read ‘For f**k’s sake, just stop oil’, the demonstrators took to the road in Parliament Square at noon today (Wednesday, September 2).
This was as Andy Burnham faced his first Prime Minister’s Questions, and many of the protestors glued themselves to the road.
The group demanded that the UK government stop approving all further oil and gas developments, and sign a Fossil Fuel Treaty to stop oil and gas extraction.
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Just Stop Oil say that the police are expected to arrest all those blocking the road, and that one lane has been left free of glued-on action takers to permit access for emergency vehicles.
Andy Burnham is due to make a decision on whether to allow more drilling for oil and gas in the North Sea.
Reverend James Crote, a Baptist Minister and grandfather from Chesterton near Bicester, said: “Today is my grandson’s first birthday. I have to take action for the sake of his future.
The 69-year-old added: “The government has been dilly-dallying about whether to say yes or no to the Rosebank oil field but, if we want a future for our children, there is no choice – it has to say ‘no’.
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“I am here as a Christian Minister because the Church has to speak out and demand that the government stops approving further oil and gas developments now. It’s time for us all to say ‘For God’s sake, Just Stop Oil’.”
Data from the Met Office indicates that 2026 was the hottest summer in UK recorded history, beating 2025, which was the previous hottest summer on record.
2026 was also one of the driest summers on record, delivering record-low food harvests.
Climbing temperatures have triggered wildfires across the country, and national fire chiefs said the wildfire risk facing the UK is “like nothing we have seen before”.
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Taking action, grandmother Victoria Ann Lynch-Staunton from Leamington Spa, said: “What is happening is beyond a tragedy.”
The 71-year-old added: “I beg everyone to join Just Stop Oil or governments will continue to prioritise endless growth and corporate profit over billions of lives – yours and your children.
“Wake up and smell the coffin. It is the responsibility of all of us to act now!”
A Just Stop Oil spokesperson said today: “We are all Just Stop Oil.
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“Every single person who fears deadly wildfires, devastating droughts, and spiralling food shortages is Just Stop Oil.
“The first duty of government is to keep the public safe – but by greenlighting oil and gas drilling, they endanger our survival while corporates and billionaires laugh their way to the bank.
“Every one of us feels alone and powerless in the face of this insanity, but we know there is massive political and public support for our demand.
“So we’re inviting everyone to join us at an online call on 3rd October 2026 – because it’s when we work together that we are powerful and win.”
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