Oxford News
Oxford scientists uncover how the brain resolves emotional ambiguity
Scientists at the University of Oxford have demonstrated, for the first time, that a key emotional centre deep in the human brain directly influences how we interpret ambiguous social cues.
In a new study, published in Neuron, researchers used low-intensity focused ultrasound to temporarily and non-invasively alter activity in the amygdala – a region known to be involved in emotion and affected in depression. They found that this changed how people responded to facial expressions, particularly when those expressions were emotionally unclear.
The findings provide rare causal evidence in humans about how the brain processes uncertainty in emotional situations, with potential implications for understanding mental health conditions.
Miriam Klein-Flügge, Associate Professor and Wellcome Henry Dale and ERC-UKRI Fellow at the Oxford Centre for Integrative Neuroimaging (OxCIN), said: ‘It has not been previously possible to change activity in deep areas of the human brain without requiring surgery. Oxford has been a key player in establishing a new, non-invasive neurostimulation technique called transcranial ultrasound stimulation (TUS), over many years, and this is the first study that applies this stimulation to the human amygdala – one of the key centres for emotion processing – while also measuring very precise neuroimaging signals to assess how we have changed the brain.’
What the study found
When the amygdala was temporarily modulated, participants became more likely to approach neutral (emotionally ambiguous) faces, suggesting they interpreted them more positively.
Participants also took longer to respond to neutral and happy faces, indicating increased difficulty distinguishing between similar emotional signals.
Brain imaging showed that stimulation reduced communication between the amygdala and other brain regions and altered its internal chemical balance.
Importantly, the effects were specific: learning from feedback was unchanged, and stimulating a different brain region produced different behavioural effects.
How the research was done
The team used a cutting-edge technique called transcranial focused ultrasound stimulation (TUS), which allows scientists to safely and precisely influence activity in deep brain regions without surgery.
Healthy volunteers received brief ultrasound stimulation targeting the amygdala before completing a behavioural task involving emotional facial expressions and decision-making. High-resolution brain scans were used to confirm that the stimulation had the intended biological effects.
The researchers measured these changes in multiple ways: they showed changes in important brain metabolites (GABA), and in the region’s functional connectivity, which indicates how it speaks to other parts of the brain. But they also showed changes in how people perceive ambiguous emotional expressions in faces.
Professor Klein-Flügge added: ‘This is a paper that we believe will shift and propel the field – the amygdala is a core region changed in mood disorders, including depression and anxiety, and while we applied ultrasound in healthy participants in this first study, an obvious next step is to see if abnormal amygdala metabolism can be restored in patients. There are still very few places worldwide that can do this type of research.
‘By showing that we can safely and precisely influence deep brain regions, this opens up exciting possibilities for future research and, potentially, new treatments. The next step is to see how these mechanisms operate in people with mood disorders.’
The researchers hope to apply this approach in clinical populations to better understand and potentially treat conditions such as depression, where emotional interpretation is often altered.
The paper, ‘Low-intensity focused ultrasound to human amygdala reveals a causal role in ambiguous emotion processing and alters local and network activity’, is published in Neuron.
The incident took place on Tuesday (June 9) in the car park of The Beacon in Wantage.
A 34-year-old man was arrested, charged, and remanded for possession with intent to supply, and his vehicle was seized.
This was after 32 wraps of Class A drugs and a “significant amount of cash” were found on him.
READ MORE: Houses evacuated as firefighters battle major blaze for over 12 hours
Thames Valley Police posted an update on their South Oxon and Vale of White Horse Facebook page this morning (Monday, June 15).
The statement said: “On June 9, 2026, our team was out looking for a vehicle that had recently piqued our interest. We located it in the car park of The Beacon.
“Now, he might have been there to pick up tickets for the open mic night, Rory Bremner, or even Noasis (who are there next week and apparently very good), but it was far more likely he was there to deal.
READ MORE: Train lines CLOSED for 7 hours amid London emergency incident
“A search confirmed our suspicions: 32 wraps of Class A and a significant amount of cash were found on him.
“Thanks to previous chases, we blocked him in early and ensured he was safely detained.
“A 34‑year‑old male from outside the area was arrested, charged, and remanded for Possession With Intent to Supply. The vehicle was seized.”
The incident occurred at around 2pm yesterday (June 13), a white and blue BMW motorcycle and a grey Audi A3 were involved in a collision.
This was near the junction of B480 Watlington Road and Pettiwell, and Thames Valley Police officers attended the scene.
There was a large emergency response with the South-Central Ambulance Service and the “Helicopter Emergency Medical Service” also present.
READ MORE: Young child hit by car and man arrested in ‘harrowing’ incident
Police say that the rider of the motorcycle was a man in his 40s and that he sustained serious life-threatening injuries.
He remains in hospital receiving treatment at this current time, Thames Valley Police informs.
The driver of the grey Audi A3 has been arrested on suspicion of causing serious injury by dangerous driving and driving whilst over the specified limit for drugs.
From Wallingford, the 51-year-old man has been released under investigation whilst enquiries continue.
READ MORE: Public warning issued and police called after stranger enters property
Thames Valley Police is now appealing for witnesses following the serious road traffic collision in Garsington.
Investigating officer, PC Kerrie Ingham of the Roads Policing Unit said: “Firstly, I would like to thank the members of the public and the medical staff who stopped to assist.
“We are carrying out a thorough investigation into the circumstances of this collision, with a man being arrested at the scene shortly after police arrived, in attendance with paramedics from SCAS and HEMS.
“I would particularly like to hear from anyone who witnessed the grey Audi A3 driving northbound to the junction of B480 Watlington Road and Pettiwell prior to the collision.
READ MORE: Warning as major protest planned for Tommy Robinson’s visit to Oxford
“I would also like to hear from anyone who witnessed the white and blue BMW motorcycle driving southbound towards the junction of the B480 Watlington Road and Pettiwell prior to the collision.
“If you saw either of these vehicles prior to the collision, or have dash-cam footage at around the time of the incident, please come forward.”
Anyone with information is asked to contact Thames Valley Police by calling 101 or submitting a report via the website, quoting reference number 43260296300.
Alternatively, you can report this anonymously via Crimestoppers on 0800 555 111.
Nestled just off Burford’s sloping High Street, The Angel at Burford stands on Witney Street in a 17th-century stone building that has welcomed locals and travellers for generations.
Records and local guides trace the inn back to around 1652, and much of that period charm remains in place today, with low ceilings, original oak beams and thick stone walls creating an intimate atmosphere inside.
Open fireplaces, polished brass and traditional pub furnishings add to the sense of history, giving drinkers and diners an authentic coaching-inn feel in the heart of the market town.
READ MORE: Legendary chef heralds shock return of closed Oxfordshire pub
Over recent years, the pub has developed into an award-winning gastropub with rooms, picking up plaudits while still functioning as a relaxed local for residents.
With a proud Hook Norton Brewery sign outside, the bar within features a line-up of the Oxfordshire brewer’s cask ales.
Separate dining areas offer a mix of cosy corners and larger tables, allowing the kitchen to serve seasonal menus that focus on classic pub dishes, Cotswold produce and modern gastropub favourites.
Beyond the interior, one of the standout attractions is the outdoor space, which is easy to miss from the street.
READ MORE: Inside refurbished Cotswolds country pub with enticing new menu
From the front bar, customers head along a corridor towards the rear of the building before emerging into a surprisingly spacious beer garden hidden behind the main frontage.
A high stone wall and surrounding buildings shelter this area, creating a secluded, almost secret walled garden that feels far removed from the bustle of Burford’s busy centre.
Landscaping has introduced planting, stone paving and plenty of wooden tables, so there is ample room for larger groups as well as quieter spots for couples and families.
Because the garden is fully enclosed and set back from the High Street, traffic noise quickly fades, so people can sit and chat in relative quiet while still being only a short walk from the centre of Burford.
READ MORE: Landlord ‘delighted’ as Rolling Stones rock legend pops into Oxford pub
On a warm Cotswolds afternoon, the garden becomes a suntrap, with visitors able to sit among the greenery and enjoy a pint of Hooky or a meal in the open air.
Many first-time guests comment on the contrast between the modest street view and the generous outdoor space tucked away at the back, making the garden a particular draw in spring and summer.
Accommodation above the pub provides a small number of letting rooms, giving people the chance to stay overnight in Burford, often described as the “Gateway to the Cotswolds”.
Combining centuries of history, traditional interiors, brewery links and a picturesque hidden beer garden, The Angel continues to serve as a popular stop-off for both local drinkers and tourists exploring this part of Oxfordshire.
European stock markets hit record high and oil price falls to three-month low after US-Iran peace deal – business live | Business
UK retail investors top up accounts ahead of SpaceX
Man arrested outside Oxfordshire theatre and charged
-
Crime & Safety4 weeks agoWhat happens to Halifax customers if Lloyds makes changes?
-
Crime & Safety4 weeks agoFlock of clay birds set to take flight in special exhibition
-
Crime & Safety4 weeks agoOxfordshire bridge closure comes as management ‘weaknesses’ found
-
Oxford News4 weeks agoActor steps down from major role in new Harry Potter series
-
Oxford News4 weeks agoHenley pub once owned by Russell Brand reopens after 6 years
-
Crime & Safety4 weeks agoFriends of the Ridgeway appoint Matthew Barber as president
-
Oxford News4 weeks agoNHS fracture service helps support extra 1,000 patients
-
UK News4 weeks agoBurnham seeks to calm markets by committing to fiscal rules